insulin resistance

noun

: reduced sensitivity to insulin by the body's insulin-dependent processes (such as glucose uptake and lipolysis) that is typical of type 2 diabetes but often occurs in the absence of diabetes

Examples of insulin resistance in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Muscle growth can also be inhibited by the downstream effects of excess fat, such as insulin resistance and the release of inflammatory molecules, Brad Schoenfeld, an exercise-science professor at Lehman College, told me. Yasmin Tayag, The Atlantic, 17 Oct. 2025 Prolonged sitting contributes to chronic inflammation, insulin resistance, and metabolic issues, even in active individuals. Fran Kritz, Verywell Health, 17 Oct. 2025 Even people who appear healthy can experience liver stress and insulin resistance if their gut microbes aren’t equipped to handle excess fructose. Khloe Quill, FOXNews.com, 12 Oct. 2025 Fiber is important for gut and heart health and can reduce insulin resistance. Brianna Tobritzhofer, Health, 7 Oct. 2025 See All Example Sentences for insulin resistance

Word History

First Known Use

1927, in the meaning defined above

Time Traveler
The first known use of insulin resistance was in 1927

Cite this Entry

“Insulin resistance.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/insulin%20resistance. Accessed 21 Oct. 2025.

Medical Definition

insulin resistance

noun
: reduced sensitivity to insulin by the body's insulin-dependent processes (as glucose uptake, lipolysis, and inhibition of glucose production by the liver) that results in decreased activity of these processes or an increase in insulin production or both and that is typical of type 2 diabetes but often occurs in the absence of diabetes
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